Human cancer genome contains thousands of noncoding mutations, including small and large Insertions and Deletions (InDels). Functional studies have revealed that some of these InDels are capable of either creating neomorphic enhancers or altering the activities of existing enhancers. 1, 2, 3
dbInDel contains 274,995 insertions and 71,603 deletions in 593,655 putative enhancers detected from 254 human and 21 murine samples based on computational analyses of H3K27ac ChIP-Seq data (for detailed information, please see Statistics). To facilitate the analysis of target transcripts of indel-containing enhancers, the website integrates mRNA expression data and survival analysis in tumor and normal samples. Moreover, our database identifies the potential recruitment of transcriptional factors as a result of enhancer-associated InDels.
Moli Huang, Yunpeng Wang, Manqiu Yang, Jun Yan, Henry Yang, Wenzhuo Zhuang, Ying Xu, H Phillip Koeffler, De-Chen Lin*, Xi Chen*. dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. Bioinformatics. 2020;36(5):1649-1651